Predictions of overloaded concentration profiles in supercritical fluid chromatography
نویسندگان
چکیده
Here, overloaded concentration profiles were predicted in supercritical fluid chromatography using a combined two-dimensional heat and mass transfer model. The balance equation provided the temperature pressure inside column. From this density, viscosity, mobile phase velocity column calculated. adsorption model is here expressed as function of density phase. system consisted Kromasil Diol packed with 2.2-µm particles (i.e., UHPSFC column) solute was phenol eluted neat carbon dioxide at three different outlet pressures five flow rates. proposed successfully all experimental runs good agreement even high-density drops along It could be concluded that radial gradients did not significantly influence elution profiles.
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ژورنال
عنوان ژورنال: Journal of Chromatography A
سال: 2021
ISSN: ['1873-3778', '0021-9673']
DOI: https://doi.org/10.1016/j.chroma.2021.461926